The article considers the main factors driving the need for government coordination of career guidance activities at the regional level, as well as the main deficits the main deficits, reflecting the lack or insufficiency of such coordination in modern Russia. Clarified the concept of «organizational-pedagogical conditions of professional self-determination» and «organizational-pedagogical support of professional self-determination». The purpose of the activities of the organizational-pedagogical support of professional self-determination is the reconciliation of interests and needs of different population groups with the interests of the economic sector and society. Describes the main tools of organizational-pedagogical support of professional self-determination: management-organizational, informational, instructional, personnel.