Results of empirical psychological study comparing motivation of the use of psychoactive substances in experimental and control groups of adolescents depending on carrying out the psycho-preventive trainings are presented. Using of psychoactive substances depends on combinative influence of many factors, most significant of which is the motivational-valuable installations which determinate addictive behavior of adolescents, and also existential values and meanings. To number of the psychological features interfering development of propensity to the use of psychoactive substances, concern: moral installations, the importance of existential values of a life, comprehension addictive behavior as dangerous to the person and for associates. The developed psycho-preventive method “preventive psychodramaˮ and on its basis the created personal focused program of trainings opens new psycho-hygienic model of prevention of substance abuse among schoolchildren. Statistically significant signs of activation of the abandonment of the use of psychoactive substances in the experimental group where the psycho-prophylactic program was conducted preventive work, proving the effectiveness of the application of this methodological approach in adolescents.