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Using two separate drugs to lose weight can be very effective you'll find combinations in front of the FDA now awaiting approval. When dealing with fat loss and the people that go through it you need to err to the side of caution and let the FDA do its job and demand some study be done so your public recognizes the side effects and perils associated with the medications before we take them. Keep in mind that drug companies have been in business to earn money and that they would say anything to keep people on the medications. Researchers found out that participants investing in this drug to get a year, dropped a few pounds within 4 weeks and have kept the weight off through the 56 weeks of the study. Contrave can be a combination in the drugs naltrexone and bupropion, which appears to reflect a brand new trend of weight-loss drugs which might be made up of multiple active ingredient, which may make them more efficient and safer. Combo-pilling may be the newest fad or in addition to this the newest ahead under scrutiny and therefore it is just more publicly known although in the past, comb-pilling for losing weight has been around since the eighties. The biggest reason that utilizing a combination of pills is becoming popular will be the fact that since right now there are no long term prescription weight loss supplements that have been approved by the FDA aside from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be approved by the FDA. Seizures are a side effect with Contrave and really should not be taken in people with seizure disorders. The drug could also raise blood pressure level and pulse rate, and mustn't be used in those with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise blood pressure and heart rate and must not used in patients with uncontrolled high blood pressure level, along with by you are not heart-related and cerebrovascular (circulation dysfunction impacting the brain) disease. Patients using a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients on the increased likelihood of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for smoking cessation. Suboxone includes two drugs; buprenorphine and naloxone. The naloxone is irrelevant when the addict uses the medication properly, but in the event the tablet is dissolved in water and injected the naloxone may cause instant withdrawal. When suboxone is employed correctly, the naloxone is destroyed inside the liver soon after uptake in the intestines and it has no therapeutic effect. Buprenorphine could be the active substance; it really is absorbed underneath the tongue (and through the mouth) but destroyed with the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I used this formulation once the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I have treated addicts who've had gastric bypass, the place that the first part of the intestine is bypassed as well as the stomach contents empty into a more distal part of the small intestine. In such cases the naloxone escapes ?first pass metabolism', the procedure with normal anatomy the location where the drug is taken up through the duodenum and transferred directly to the liver with the portal vein, where it is quickly and completely destroyed. After gastric bypass naloxone can be taken on by areas of the intestine that aren't served by the portal system, causing blood levels of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.