In the article it is shown that for increasing in effectiveness and result of the means of training and instruction in the culture of the safe and healthy means of life is necessary the individualization and the differentiation of the use of pedagogical means and methods on the basis of the analysis of the social, psychophysiological and pedagogical factors, which impede or which facilitate the realization of this process. The creation of conditions for the psycho-social and physiological adaptation of students, T. becomes the most important task of the psychological and pedagogical trackingAnnotation. In the article it is shown that for increasing in effectiveness and result of the means of training and instruction in the culture of the safe and healthy means of life is necessary the individualization and the differentiation of the use of pedagogical means and methods on the basis of the analysis of the social, psychophysiological and pedagogical factors, which impede or which facilitate the realization of this process. The creation of conditions for the psycho-social and physiological adaptation of students, T. becomes the most important task of the psychological and pedagogical tracking of instruction. e. their capability for self-development and self-perfection, maintenance of their health. The complex of the neurodynamic indices was analyzed: the latent period of simple visual-motor reaction (LPPZMR, ms.), the level of the mobility of nervous processes (UFP, ms.), the steadiness of nervous (RDO), the fitness for work of brain (RGM, the quantity of signals); the psycho-dynamic indices: the level of memory, the level of attention with the aid of the automated software-and-hardware complex “Status- pF”. The obtained results make it possible to isolate some summary components, which are concerned the special features of the vegetative guarantee of a process of psycho-social and physiological adaptation in the schoolboys of the fifth and eighth classes with different initial vegetative tone.